Hypokinesia produced by anterolateral hypothalamic 6-hydroxydopamine lesions and its reversal by some antiparkinson drugs
Identifieur interne : 005275 ( Main/Exploration ); précédent : 005274; suivant : 005276Hypokinesia produced by anterolateral hypothalamic 6-hydroxydopamine lesions and its reversal by some antiparkinson drugs
Auteurs : Roger F. Butterworth [Canada] ; Ferdinand Bélanger [Canada] ; André Barbeau [Canada]Source :
- [ 0091-3057 ]
Abstract
Hypokinesia produced by stereotaxic microinjection of solutions of 6-hydroxydopamine into the anterolateral hypothalamus of male rats is accompanied by a generalized reduction in brain noradrenaline levels and a reduction of dopamine in the striatum and cerebral cortex. The hypokinesia is reversed by the putative dopamine-receptor agonists apomorphine, ET-495 and CB-154 as well as by the amino acids L-Dopa and m-tyrosine when administered in combination with the peripheral decarboxylase inhibitor Ro 4–4602. The relative importance of noradrenergic and dopaminergic systems in the mediation of the action of anti-akinesia drugs is discussed.
Url:
DOI: 10.1016/0091-3057(78)90121-1
Affiliations:
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